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Malaria’s Deadly Weapon

Posted by iskanbasal on August 16, 2007

“A molecule that constantly reinvents itself is one of the many ingenious mechanisms that P. falciparum – the mosquito-borne blood parasite that causes the deadliest form of human malaria — has evolved to protect itself against the human immune system. A new understanding of how this morphing molecule helps the parasite survive inside red blood cells could help scientists develop new treatments for the disease”.

See what intelligent strategy the parasite has to escape being destroyed: “The researchers found that PfEMP-1 also causes infected red blood cells to stick to the endothelial cells that line blood vessels. By sticking to blood vessel walls, infected erythrocytes avoid passing through the spleen where they would be filtered out and destroyed”.

Most important we know a molecule that suppresses the production of IFN-gamma but not the other cytokines, a biological mechanism in which it is suppressed. But see also how intriguing are the genetic studies performed by the researchers on the parasite.

This is what recently publishes the Howard Hughes Medical Institute.

(Escuse me my English errors).


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