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Iron homeostasis: Fitting the puzzle pieces together

Posted by iskanbasal on September 25, 2008

Iron homeostasis: fitting the puzzle pieces together.Tomas Ganz

Cell Metabolism Volume 7 issue 4 9 april 2008 pages 288-290

PMID: 18396134 Put this in Pubmed to reach the article.

doi:10.1016/j.cmet.2008.03.008 .

A brief piece of the article:

“Here, recent insights into iron homeostasis are highlighted. Three studies demonstrate the importance of the IRE-IRP system for enterocytes in balancing extracellular iron demand against cellular iron requirements, show that the hemochromatosis protein HFE exerts its iron-regulatory activity principally in hepatocytes by modulating the production of hepcidin, and provide strong support for a proposed mechanism of transcriptional regulation of hepcidin through a signaling cascade initiated by holotransferrin displacing HFE from transferrin receptor 1.”

I finished reading the above article and after three times reading the text I now can assure I understood the pieces that make together the iron metabolism in our organisms. It is an interesting subject and I reached here while preparing for a material in medicine : ” lab tests and the interpretation of diagnostic tests”.

I searched for the word Hepcidin in the MeSH database of the Pubmed and I only found this definition:

“a urinary antimicrobial peptide synthesized in the liver; may play a role in the regulation of iron metabolism; amino acid sequence in first source
Date introduced: June 15, 2001”.

I will update this post in the next days with more definitions of my understandings in the subject.


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