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Concepts in Cardiovascular Physiology

Posted by iskanbasal on December 23, 2008

From Cardiovascular Physiology by David  E. Mohrman:

“A common misconception in cardiovascular physiology is that the systolic pressure alone or the diastolic pressure alone indicates the status of a specific cardiovascular variable. For example, high diastolic pressure is often taken to indicate high total peripheral resistance. This is not necessarily so since high diastolic pressure can exist with normal (or even reduced) total peripheral resistance if heart rate and cardiac output are high. Both systolic pressure and diastolic pressure are influenced by heart rate, stroke volume, total peripheral resistance, and CA ( compliance). The student should not attempt to interpret systolic and diastolic pressure values independently. Interpretation is much more straightforward when the focus is on mean arterial pressure:

PA = CO x TPR and arterial pulse pressure: Pp= SV/CA.”

I really always thought the diastolic pressure as indicator of the total peripheral resistances, which is a specific cardiovascular variable, without thinking about it in the way the author is explaining it in the above piece.

Some more concepts:

“Turbulent blood flow is abnormal and makes noise (murmurs and bruits)”.

(the normal blood flow is the laminar one)

“Veins contain most of the total blood volume”.

“Because arteries are elastic, the intermittent flow from the heart is converted to continuous flow through capillaries.”

“Mean systemic arterial pressure is determined by the product of cardiac output and total peripheral resistance.”

“Changes in arterial pulse pressure reflect changes in stroke volume and/or the compliance of the arterial space.”

I’m now going to review an another chapter in the same book: the “Vascular Control” and “the central venous pressure” which was my aim of reviewing.


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