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When high is low: Raising low levels of high-density lipoprotein cholesterol

Posted by iskanbasal on January 21, 2009

This is an interersting article to read on this subject, low levels of HDL-C as a risk factor for cardiovascular disease and how to raise them. Thanks to MDLinks.

Low serum levels of high-density lipoprotein cholesterol (HDL-C) are highly prevalent and are recognized as an independent risk factor for cardiovascular morbidity (myocardial infarction, stroke, peripheral arterial disease, and restenosis after coronary stenting) and mortality. HDL plays an important role in modulating atherogenesis, although its functions are varied and complex and the mechanisms for its antiatherogenic effects have not been completely elucidated. The inverse relationship between HDL-C and cardiovascular risk is well established, and epidemiologic studies and clinical trials have provided ample evidence that higher levels of HDL-C are vasculoprotective. Although considerable interest exists in the development of novel approaches to raise serum HDL-C and to augment HDL functionality, this article discusses currently available therapies to raise suboptimal levels of this important lipoprotein.

The article is cited:

Journal Title  – Current Cardiology Reports
Article Title  – When high is low: Raising low levels of high-density lipoprotein cholesterol
Volume  – Volume 10
Issue  – 6
First Page  – 488
Last Page  – 496
Issue Cover Date  – 2008-11-01

Author  – Peter P. Toth
DOI  – 10.1007/s11886-008-0077-2
Link  – http://www.metapress.com/content/b7xk865071252854

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