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Prealbumin (PAB)

Posted by iskanbasal on March 17, 2009

First it was established that to assess the nutritional status of a critically ill patient admitted to the ICU or to surgery it was necessary to determine albumin, prealbumin, C -reactive protein and retinol-binding protein. Prealbumin is considered the better choice for this purpose, why?

Albumin has a half-life of 21 days, it is slow to respond to changes while PAB has a half-life of 2 days and respond quickly to any change in the nutritional status of the patients.

Reference values:

Values of 0 to 5, 5 to 10 and 10 to 15 mg/dL indicate severe, moderate and mild protein depletion respectively.

Moreover, I understand that PAB is used to determine in a traumatic patient that the losing liquid from their nose is a cerebrospinal fluid (CSF) by the determination of the concentration of PAB in it.

I’m studying some chapters in lab medicine and diagnostic testing.


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