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Posted by iskanbasal on March 31, 2009

Macroenzymes, what are they?

“Macroenzymes are enzymes in plasma that have a higher molecular mass than the corresponding enzyme normally present under (patho) physiological conditions. They may arise through self-polymerization or by association with other plasma components, in particular immunoglobulins”.

This citation from an article:

“A paediatric case of macro aspartate aminotransferase”

Read the article here doi:10.1258/acb.2007.007094 Ann Clin Biochem 2008;45:323-324

Why I’m interested? I encountered this subject during studying for liver function tests after having finished the disorderds of lipid metabolism which I posted about below.

Type-1 macroenzymes result from the formation of antigen-antibody complexes, using GPT, GOT, gama-GT, and AP

Type-2 macroenzymes result from oligomerization using gama-GT, AP, LAP and 5′-NU.

In the absence of clinical findings continuous elevation of measured GPT(and also GOT) is found with the appearance of macroenzymes.


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